HIF is not essential for suppression of experimental tumor growth by mTOR inhibition

The Hypoxia Inducible Transcription Factor (HIF) is the master regulator of cellular response to hypoxic adaptation. Solid tumors inevitably harbour hypoxic regions with subsequent stabilization and activation of HIF and HIF target genes due to poor vascularization and rapid growth. The mammalian ta...

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Bibliografiske detaljer
Udgivet i:J Cancer
Main Authors: Knaup, Karl X., Guenther, Regina, Stoeckert, Johanna, Monti, Juliana M., Eckardt, Kai-Uwe, Wiesener, Michael S.
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5556644/
https://ncbi.nlm.nih.gov/pubmed/28819378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.16486
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