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HIF is not essential for suppression of experimental tumor growth by mTOR inhibition
The Hypoxia Inducible Transcription Factor (HIF) is the master regulator of cellular response to hypoxic adaptation. Solid tumors inevitably harbour hypoxic regions with subsequent stabilization and activation of HIF and HIF target genes due to poor vascularization and rapid growth. The mammalian ta...
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| Publicado no: | J Cancer |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Ivyspring International Publisher
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5556644/ https://ncbi.nlm.nih.gov/pubmed/28819378 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.16486 |
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