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Activated Ion Electron Transfer Dissociation Enables Comprehensive Top-Down Protein Fragmentation

Here we report the first demonstration of near-complete sequence coverage of intact proteins using activated ion-electron transfer dissociation (AI-ETD), a method that leverages concurrent infrared photo-activation to enhance electron-driven dissociation. AI-ETD produces mainly c/z-type product ions...

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Publicat a:J Proteome Res
Autors principals: Riley, Nicholas M., Westphall, Michael S., Coon, Joshua J.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555583/
https://ncbi.nlm.nih.gov/pubmed/28608681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jproteome.7b00249
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