Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle

Bacteria stimulate macrophages as part of normal host defense. However, when this response is not limited, vascular smooth muscle may also be activated to express “vasoactive” genes (e.g., cyclooxygenase), leading to vascular collapse and septic shock. In macrophages, Toll-like receptors (TLRs) 4 an...

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Main Authors: Jimenez, Rosario, Belcher, Elizabeth, Sriskandan, Shiranee, Lucas, Ruth, McMaster, Shaun, Vojnovic, Ivana, Warner, Timothy D., Mitchell, Jane A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC555494/
https://ncbi.nlm.nih.gov/pubmed/15755814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407655101
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