Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle

Bacteria stimulate macrophages as part of normal host defense. However, when this response is not limited, vascular smooth muscle may also be activated to express “vasoactive” genes (e.g., cyclooxygenase), leading to vascular collapse and septic shock. In macrophages, Toll-like receptors (TLRs) 4 an...

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Detalhes bibliográficos
Main Authors: Jimenez, Rosario, Belcher, Elizabeth, Sriskandan, Shiranee, Lucas, Ruth, McMaster, Shaun, Vojnovic, Ivana, Warner, Timothy D., Mitchell, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC555494/
https://ncbi.nlm.nih.gov/pubmed/15755814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407655101
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