Cancer progression by reprogrammed BCAA metabolism in myeloid leukemia

Reprogrammed cellular metabolism is a common characteristic observed in various cancers(1,2). However, whether metabolic changes directly regulate cancer development and progression remains poorly understood. Here we show that BCAT1, a cytosolic aminotransferase for the branched-chain amino acids (B...

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Veröffentlicht in:Nature
Hauptverfasser: Hattori, Ayuna, Tsunoda, Makoto, Konuma, Takaaki, Kobayashi, Masayuki, Nagy, Tamas, Glushka, John, Tayyari, Fariba, McSkimming, Daniel, Kannan, Natarajan, Tojo, Arinobu, Edison, Arthur S., Ito, Takahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554449/
https://ncbi.nlm.nih.gov/pubmed/28514443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22314
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