Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here we show that EZH2 and NRas(G12D) mutations cooperatively induce progression of myeloproliferative neoplasms to highly...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Gu, Zhimin, Liu, Yuxuan, Cai, Feng, Patrick, McKenzie, Zmajkovic, Jakub, Cao, Hui, Zhang, Yuannyu, Tasdogan, Alpaslan, Chen, Mingyi, Qi, Le, Liu, Xin, Li, Kailong, Lyu, Junhua, Dickerson, Kathryn E., Chen, Weina, Ni, Min, Merritt, Matthew E., Morrison, Sean J., Skoda, Radek C., DeBerardinis, Ralph J., Xu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726547/
https://ncbi.nlm.nih.gov/pubmed/31189531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0152
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