Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here we show that EZH2 and NRas(G12D) mutations cooperatively induce progression of myeloproliferative neoplasms to highly...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cancer Discov
Päätekijät: Gu, Zhimin, Liu, Yuxuan, Cai, Feng, Patrick, McKenzie, Zmajkovic, Jakub, Cao, Hui, Zhang, Yuannyu, Tasdogan, Alpaslan, Chen, Mingyi, Qi, Le, Liu, Xin, Li, Kailong, Lyu, Junhua, Dickerson, Kathryn E., Chen, Weina, Ni, Min, Merritt, Matthew E., Morrison, Sean J., Skoda, Radek C., DeBerardinis, Ralph J., Xu, Jian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726547/
https://ncbi.nlm.nih.gov/pubmed/31189531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0152
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