Loss of EZH2 Reprograms BCAA Metabolism to Drive Leukemic Transformation

Epigenetic gene regulation and metabolism are highly intertwined, yet little is known about whether altered epigenetics influence cellular metabolism during cancer progression. Here we show that EZH2 and NRas(G12D) mutations cooperatively induce progression of myeloproliferative neoplasms to highly...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Discov
Egile Nagusiak: Gu, Zhimin, Liu, Yuxuan, Cai, Feng, Patrick, McKenzie, Zmajkovic, Jakub, Cao, Hui, Zhang, Yuannyu, Tasdogan, Alpaslan, Chen, Mingyi, Qi, Le, Liu, Xin, Li, Kailong, Lyu, Junhua, Dickerson, Kathryn E., Chen, Weina, Ni, Min, Merritt, Matthew E., Morrison, Sean J., Skoda, Radek C., DeBerardinis, Ralph J., Xu, Jian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6726547/
https://ncbi.nlm.nih.gov/pubmed/31189531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-19-0152
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