Using local chromatin structure to improve CRISPR/Cas9 efficiency in zebrafish

Although the CRISPR/Cas9 has been successfully applied in zebrafish, considerable variations in efficiency have been observed for different gRNAs. The workload and cost of zebrafish mutant screening is largely dependent on the mutation rate of injected embryos; therefore, selecting more effective gR...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chen, Yunru, Zeng, Shiyang, Hu, Ruikun, Wang, Xiangxiu, Huang, Weilai, Liu, Jiangfang, Wang, Luying, Liu, Guifen, Cao, Ying, Zhang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553855/
https://ncbi.nlm.nih.gov/pubmed/28800611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182528
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