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Chromatin accessibility is associated with CRISPR-Cas9 efficiency in the zebrafish (Danio rerio)
CRISPR-Cas9 technology is routinely applied for targeted mutagenesis in model organisms and cell lines. Recent studies indicate that the prokaryotic CRISPR-Cas9 system is affected by eukaryotic chromatin structures. Here, we show that the likelihood of successful mutagenesis correlates with transcri...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5912780/ https://ncbi.nlm.nih.gov/pubmed/29684067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0196238 |
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