Using local chromatin structure to improve CRISPR/Cas9 efficiency in zebrafish

Although the CRISPR/Cas9 has been successfully applied in zebrafish, considerable variations in efficiency have been observed for different gRNAs. The workload and cost of zebrafish mutant screening is largely dependent on the mutation rate of injected embryos; therefore, selecting more effective gR...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Chen, Yunru, Zeng, Shiyang, Hu, Ruikun, Wang, Xiangxiu, Huang, Weilai, Liu, Jiangfang, Wang, Luying, Liu, Guifen, Cao, Ying, Zhang, Yong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5553855/
https://ncbi.nlm.nih.gov/pubmed/28800611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182528
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