Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions

Control of phosphate metabolism is crucial to regulate aging in mammals. Klotho is a well-known anti-aging factor that regulates phosphate metabolism: mice mutant or deficient in Klotho exhibit phenotypes resembling human aging. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 1 (E...

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Udgivet i:Sci Rep
Main Authors: Watanabe, Ryuichi, Fujita, Nobuyuki, Sato, Yuiko, Kobayashi, Tami, Morita, Mayu, Oike, Takatsugu, Miyamoto, Kana, Kuro-o, Makoto, Michigami, Toshimi, Fukumoto, Seiji, Tsuji, Takashi, Toyama, Yoshiaki, Nakamura, Masaya, Matsumoto, Morio, Miyamoto, Takeshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5552841/
https://ncbi.nlm.nih.gov/pubmed/28798354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07341-2
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