Smad2/3 Proteins Are Required for Immobilization-induced Skeletal Muscle Atrophy

Skeletal muscle atrophy promotes muscle weakness, limiting activities of daily living. However, mechanisms underlying atrophy remain unclear. Here, we show that skeletal muscle immobilization elevates Smad2/3 protein but not mRNA levels in muscle, promoting atrophy. Furthermore, we demonstrate that...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tando, Toshimi, Hirayama, Akiyoshi, Furukawa, Mitsuru, Sato, Yuiko, Kobayashi, Tami, Funayama, Atsushi, Kanaji, Arihiko, Hao, Wu, Watanabe, Ryuichi, Morita, Mayu, Oike, Takatsugu, Miyamoto, Kana, Soga, Tomoyoshi, Nomura, Masatoshi, Yoshimura, Akihiko, Tomita, Masaru, Matsumoto, Morio, Nakamura, Masaya, Toyama, Yoshiaki, Miyamoto, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933268/
https://ncbi.nlm.nih.gov/pubmed/27129272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.680579
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