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Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage

The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for its role in cytoplasmic microRNA production. Recent findings suggest that noncanonical Dicer generates small noncoding RNA to mediate the DNA damage response (DDR). Here, we show that human Dicer is...

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Foilsithe in:J Cell Biol
Main Authors: Burger, Kaspar, Schlackow, Margarita, Potts, Martin, Hester, Svenja, Mohammed, Shabaz, Gullerova, Monika
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Rockefeller University Press 2017
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551710/
https://ncbi.nlm.nih.gov/pubmed/28642363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612131
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