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Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage

The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for its role in cytoplasmic microRNA production. Recent findings suggest that noncanonical Dicer generates small noncoding RNA to mediate the DNA damage response (DDR). Here, we show that human Dicer is...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Cell Biol
Päätekijät: Burger, Kaspar, Schlackow, Margarita, Potts, Martin, Hester, Svenja, Mohammed, Shabaz, Gullerova, Monika
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551710/
https://ncbi.nlm.nih.gov/pubmed/28642363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612131
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