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Nuclear phosphorylated Dicer processes double-stranded RNA in response to DNA damage

The endoribonuclease Dicer is a key component of the human RNA interference pathway and is known for its role in cytoplasmic microRNA production. Recent findings suggest that noncanonical Dicer generates small noncoding RNA to mediate the DNA damage response (DDR). Here, we show that human Dicer is...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Burger, Kaspar, Schlackow, Margarita, Potts, Martin, Hester, Svenja, Mohammed, Shabaz, Gullerova, Monika
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551710/
https://ncbi.nlm.nih.gov/pubmed/28642363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612131
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