Thymic progenitors of TCRαβ(+) CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development

Strong T cell receptor (TCR) signaling largely induces cell death during thymocyte development, whereas weak TCR signals induce positive selection. However, some T cell lineages require strong TCR signals for differentiation through a process termed agonist selection. The signaling relationships tha...

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Bibliografski detalji
Izdano u:J Exp Med
Glavni autori: Golec, Dominic P., Hoeppli, Romy E., Henao Caviedes, Laura M., McCann, Jillian, Levings, Megan K., Baldwin, Troy A.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5551581/
https://ncbi.nlm.nih.gov/pubmed/28652304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170844
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