Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ(+)CD8αα(+) T cells

Intestinal intraepithelial lymphocytes (IELs) expressing CD8αα on αβ T cells (TCRαβ(+)CD8αα(+) IELs) have suppressive capabilities in enterocolitis, but the mechanism that maintains homeostasis and cell number is not fully understood. Here, we demonstrated that the number of TCRαβ(+)CD8αα(+) IELs wa...

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Dettagli Bibliografici
Pubblicato in:PLoS Biol
Autori principali: Ishifune, Chieko, Tsukumo, Shin-ichi, Maekawa, Yoichi, Hozumi, Katsuto, Chung, Doo Hyun, Motozono, Chihiro, Yamasaki, Sho, Nakano, Hiroyasu, Yasutomo, Koji
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6529014/
https://ncbi.nlm.nih.gov/pubmed/31071093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000262
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