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ATP depletion is the major cause of MPP(+) induced dopamine neuronal death and worm lethality in α-synuclein transgenic C. elegans
OBJECTIVE: To investigate the toxic effect of environmental neurotoxin MPP(+) to C. elegans and identify the mechanisms that cause the toxicity. METHODS: Human α-synuclein transgenic C. elegans was used as the animal model, the toxic effect of MPP(+) to dopamine (DA) neurons and the lifespan of worm...
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| Publicado no: | Neurosci Bull |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5550646/ https://ncbi.nlm.nih.gov/pubmed/18064062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12264-007-0049-3 |
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