Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations

Therapeutic targeting of the phosphoinositide 3-kinase (PI3K) pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA...

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Publicado en:Mol Cancer Res
Main Authors: Foley, Tyler M., Payne, Susan N., Pasch, Cheri A., Yueh, Alex E., Van De Hey, Dana R., Korkos, Demetra P., Clipson, Linda, Maher, Molly E., Matkowskyj, Kristina A., Newton, Michael A., Deming, Dustin A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550373/
https://ncbi.nlm.nih.gov/pubmed/28184015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-16-0256
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