Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress

Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross anatomical or neuronal abnormalities. Dopaminergic neuron numbers in the substantia nigra and fiber densities and...

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Autori principali: Kim, Raymond H., Smith, Patrice D., Aleyasin, Hossein, Hayley, Shawn, Mount, Matthew P., Pownall, Scott, Wakeham, Andrew, You-Ten, Annick J., Kalia, Suneil K., Horne, Patrick, Westaway, David, Lozano, Andres M., Anisman, Hymie, Park, David S., Mak, Tak W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2005
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC555037/
https://ncbi.nlm.nih.gov/pubmed/15784737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501282102
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