DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathway

Loss-of-function DJ-1 (PARK7) mutations have been linked with a familial form of early onset Parkinson disease. Numerous studies have supported the role of DJ-1 in neuronal survival and function. Our initial studies using DJ-1-deficient neurons indicated that DJ-1 specifically protects the neurons a...

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Detalhes bibliográficos
Main Authors: Aleyasin, Hossein, Rousseaux, Maxime W. C., Marcogliese, Paul C., Hewitt, Sarah J., Irrcher, Isabella, Joselin, Alvin P., Parsanejad, Mohammad, Kim, Raymond H., Rizzu, Patrizia, Callaghan, Steve M., Slack, Ruth S., Mak, Tak W., Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2010
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2840364/
https://ncbi.nlm.nih.gov/pubmed/20133695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914876107
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