Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP

PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a mitochondrial localization sequence and is reported to reside, at least in part, in mitochondria. However, neither the manner by which the...

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Detalhes bibliográficos
Main Authors: Haque, M. Emdadul, Thomas, Kelly J., D'Souza, Cheryl, Callaghan, Steve, Kitada, Tohru, Slack, Ruth S., Fraser, Paul, Cookson, Mark R., Tandon, Anurag, Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234210/
https://ncbi.nlm.nih.gov/pubmed/18218782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705363105
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