Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1

Mutations in the mitochondrial PTEN-induced kinase 1 (Pink1) gene have been linked to Parkinson disease (PD). Recent reports including our own indicated that ectopic Pink1 expression is protective against toxic insult in vitro, suggesting a potential role for endogenous Pink1 in mediating survival....

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Bibliografiske detaljer
Main Authors: Haque, M. Emdadul, Mount, Matthew P., Safarpour, Farzaneh, Abdel-Messih, Elizabeth, Callaghan, Steve, Mazerolle, Chantal, Kitada, Tohru, Slack, Ruth S., Wallace, Valerie, Shen, Jie, Anisman, Hymie, Park, David S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Neurobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3391096/
https://ncbi.nlm.nih.gov/pubmed/22511790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.346437
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