Perturbation of Transcription Factor Nur77 Expression Mediated by Myocyte Enhancer Factor 2D (MEF2D) Regulates Dopaminergic Neuron Loss in Response to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

We have earlier reported the critical nature of calpain-CDK5-MEF2 signaling in governing dopaminergic neuronal loss in vivo. CDK5 mediates phosphorylation of the neuronal survival factor myocyte enhancer factor 2 (MEF2) leading to its inactivation and loss. However, the downstream factors that media...

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Detalhes bibliográficos
Main Authors: Mount, Matthew P., Zhang, Yi, Amini, Mandana, Callaghan, Steve, Kulczycki, Jerzy, Mao, Zixu, Slack, Ruth S., Anisman, Hymie, Park, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656291/
https://ncbi.nlm.nih.gov/pubmed/23536182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.439216
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