DJ-1 Interacts with and Regulates Paraoxonase-2, an Enzyme Critical for Neuronal Survival in Response to Oxidative Stress

Loss-of-function mutations in DJ-1 (PARK7) gene account for about 1% of all familial Parkinson's disease (PD). While its physiological function(s) are not completely clear, DJ-1 protects neurons against oxidative stress in both in vitro and in vivo models of PD. The molecular mechanism(s) throu...

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Main Authors: Parsanejad, Mohammad, Bourquard, Noam, Qu, Dianbo, Zhang, Yi, Huang, En, Rousseaux, Maxime W. C., Aleyasin, Hossein, Irrcher, Isabella, Callaghan, Steve, Vaillant, Dominique C., Kim, Raymond H., Slack, Ruth S., Mak, Tak W., Reddy, Srinivasa T., Figeys, Daniel, Park, David S.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4161380/
https://ncbi.nlm.nih.gov/pubmed/25210784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0106601
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