Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs over multiple stages of embryogenesis in two dist...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Khoueiry, Pierre, Girardot, Charles, Ciglar, Lucia, Peng, Pei-Chen, Gustafson, E Hilary, Sinha, Saurabh, Furlong, Eileen EM
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Genes and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550276/
https://ncbi.nlm.nih.gov/pubmed/28792889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28440
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