Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

Sequence variation within enhancers plays a major role in both evolution and disease, yet its functional impact on transcription factor (TF) occupancy and enhancer activity remains poorly understood. Here, we assayed the binding of five essential TFs over multiple stages of embryogenesis in two dist...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Khoueiry, Pierre, Girardot, Charles, Ciglar, Lucia, Peng, Pei-Chen, Gustafson, E Hilary, Sinha, Saurabh, Furlong, Eileen EM
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Genes and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550276/
https://ncbi.nlm.nih.gov/pubmed/28792889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28440
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