Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes

Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate highly interconnected pathways with ample cross-talk....

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Publicat a:PLoS Comput Biol
Autors principals: Mbodj, Abibatou, Gustafson, E. Hilary, Ciglar, Lucia, Junion, Guillaume, Gonzalez, Aitor, Girardot, Charles, Perrin, Laurent, Furlong, Eileen E. M., Thieffry, Denis
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012701/
https://ncbi.nlm.nih.gov/pubmed/27599298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005073
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