Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes

Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate highly interconnected pathways with ample cross-talk....

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Détails bibliographiques
Publié dans:PLoS Comput Biol
Auteurs principaux: Mbodj, Abibatou, Gustafson, E. Hilary, Ciglar, Lucia, Junion, Guillaume, Gonzalez, Aitor, Girardot, Charles, Perrin, Laurent, Furlong, Eileen E. M., Thieffry, Denis
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012701/
https://ncbi.nlm.nih.gov/pubmed/27599298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005073
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