Qualitative Dynamical Modelling Can Formally Explain Mesoderm Specification and Predict Novel Developmental Phenotypes

Given the complexity of developmental networks, it is often difficult to predict the effect of genetic perturbations, even within coding genes. Regulatory factors generally have pleiotropic effects, exhibit partially redundant roles, and regulate highly interconnected pathways with ample cross-talk....

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Dettagli Bibliografici
Pubblicato in:PLoS Comput Biol
Autori principali: Mbodj, Abibatou, Gustafson, E. Hilary, Ciglar, Lucia, Junion, Guillaume, Gonzalez, Aitor, Girardot, Charles, Perrin, Laurent, Furlong, Eileen E. M., Thieffry, Denis
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5012701/
https://ncbi.nlm.nih.gov/pubmed/27599298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005073
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