Transgene Expression in Dogs After Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters

The Sleeping Beauty transposon system has been extensively tested for integration of reporter and therapeutic genes in vitro and in vivo in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solutions. DNA solutions were delivered into the entire li...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther
Main Authors: Hyland, Kendra A., Aronovich, Elena L., Olson, Erik R., Bell, Jason B., Rusten, Myra Urness, Gunther, Roland, Hunter, David W., Hackett, Perry B., McIvor, R. Scott
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549801/
https://ncbi.nlm.nih.gov/pubmed/28447859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.003
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