Transgene Expression in Dogs After Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters

The Sleeping Beauty transposon system has been extensively tested for integration of reporter and therapeutic genes in vitro and in vivo in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solutions. DNA solutions were delivered into the entire li...

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發表在:Hum Gene Ther
Main Authors: Hyland, Kendra A., Aronovich, Elena L., Olson, Erik R., Bell, Jason B., Rusten, Myra Urness, Gunther, Roland, Hunter, David W., Hackett, Perry B., McIvor, R. Scott
格式: Artigo
語言:Inglês
出版: Mary Ann Liebert, Inc. 2017
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Research Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549801/
https://ncbi.nlm.nih.gov/pubmed/28447859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.003
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