Transgene Expression in Dogs After Liver-Directed Hydrodynamic Delivery of Sleeping Beauty Transposons Using Balloon Catheters

The Sleeping Beauty transposon system has been extensively tested for integration of reporter and therapeutic genes in vitro and in vivo in mice. Dogs were used as a large animal model for human therapy and minimally invasive infusion of DNA solutions. DNA solutions were delivered into the entire li...

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Publicado en:Hum Gene Ther
Autores principales: Hyland, Kendra A., Aronovich, Elena L., Olson, Erik R., Bell, Jason B., Rusten, Myra Urness, Gunther, Roland, Hunter, David W., Hackett, Perry B., McIvor, R. Scott
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2017
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549801/
https://ncbi.nlm.nih.gov/pubmed/28447859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.003
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