Efficacy and Safety of Sleeping Beauty Transposon-Mediated Gene Transfer in Preclinical Animal Studies

Sleeping Beauty (SB) transposons have been effective in delivering therapeutic genes to treat certain diseases in mice. Hydrodynamic gene delivery of integrating transposons to 5–20% of the hepatocytes in a mouse results in persistent elevated expression of the therapeutic polypeptides that can be s...

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Hauptverfasser: Hackett, Perry B., Aronovich, Elena L., Hunter, David, Urness, Myra, Bell, Jason B., Kass, Steven J., Cooper, Laurence J.N., McIvor, R. Scott
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3728161/
https://ncbi.nlm.nih.gov/pubmed/21888621
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