Age-associated DNA methylation changes in naive CD4(+) T cells suggest an evolving autoimmune epigenotype in aging T cells

AIM: We sought to define age-associated DNA methylation changes in naive CD4(+) T cells. MATERIALS & METHODS: Naive CD4(+) T cells were collected from 74 healthy individuals (age 19–66 years), and age-related DNA methylation changes were characterized. RESULTS: We identified 11,431 age-associate...

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Veröffentlicht in:Epigenomics
Hauptverfasser: Dozmorov, Mikhail G, Coit, Patrick, Maksimowicz-McKinnon, Kathleen, Sawalha, Amr H
Format: Artigo
Sprache:Inglês
Veröffentlicht: Future Medicine Ltd 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5549647/
https://ncbi.nlm.nih.gov/pubmed/28322571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2016-0143
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