Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients

Systemic lupus erythematosus is an autoimmune disease characterized by multi-system involvement and autoantibody production. Abnormal T cell DNA methylation and type-I interferon play an important role in the pathogenesis of lupus. We performed a genome-wide DNA methylation study in two independent...

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Detalhes bibliográficos
Main Authors: Coit, Patrick, Jeffries, Matlock, Altorok, Nezam, Dozmorov, Mikhail G., Koelsch, Kristi A., Wren, Jonathan D., Merrill, Joan T., McCune, W. Joseph, Sawalha, Amr H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790645/
https://ncbi.nlm.nih.gov/pubmed/23623029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.04.003
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