Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naïve CD4+ T cells from lupus patients

Systemic lupus erythematosus is an autoimmune disease characterized by multi-system involvement and autoantibody production. Abnormal T cell DNA methylation and type-I interferon play an important role in the pathogenesis of lupus. We performed a genome-wide DNA methylation study in two independent...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Coit, Patrick, Jeffries, Matlock, Altorok, Nezam, Dozmorov, Mikhail G., Koelsch, Kristi A., Wren, Jonathan D., Merrill, Joan T., McCune, W. Joseph, Sawalha, Amr H.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2013
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790645/
https://ncbi.nlm.nih.gov/pubmed/23623029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2013.04.003
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares