DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus

OBJECTIVE: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by heterogeneous clinical manifestations, autoantibody production and epigenetic dysregulation in T cells. We sought to investigate the epigenetic contribution to the development of cutaneous manifestations i...

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Detalhes bibliográficos
Publicado no:Lupus Sci Med
Main Authors: Renauer, Paul, Coit, Patrick, Jeffries, Matlock A, Merrill, Joan T, McCune, W Joseph, Maksimowicz-McKinnon, Kathleen, Sawalha, Amr H
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577980/
https://ncbi.nlm.nih.gov/pubmed/26405558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/lupus-2015-000101
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