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Epigenetic reprogramming in naïve CD4+ T cells favoring T cell activation and non-Th1 effector T cell immune response as an early event in lupus flares

OBJECTIVE: Systemic lupus erythematosus is a relapsing autoimmune disease that affects multiple organ systems. T cells play an important role in the pathogenesis of lupus, however, early T cell events triggering disease flares are incompletely understood. We studied DNA methylation in naïve CD4+ T c...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Coit, Patrick, Dozmorov, Mikhail G., Merrill, Joan T., McCune, W. Joseph, Maksimowicz-McKinnon, Kathleen, Wren, Jonathan D., Sawalha, Amr H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001909/
https://ncbi.nlm.nih.gov/pubmed/27111767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.39720
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