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A novel region in the Ca(V)2.1 α(1) subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is principally mediated by Ca(V)2.1 calcium channels (Ca(V)2.1) and is highly dependent on the physical distance between Ca(V)2.1 and synaptic vesicles (coupling). Although various active zone proteins are pro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Lübbert, Matthias, Goral, R Oliver, Satterfield, Rachel, Putzke, Travis, van den Maagdenberg, Arn MJM, Kamasawa, Naomi, Young, Samuel M
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548488/
https://ncbi.nlm.nih.gov/pubmed/28786379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28412
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