A novel region in the Ca(V)2.1 α(1) subunit C-terminus regulates fast synaptic vesicle fusion and vesicle docking at the mammalian presynaptic active zone

In central nervous system (CNS) synapses, action potential-evoked neurotransmitter release is principally mediated by Ca(V)2.1 calcium channels (Ca(V)2.1) and is highly dependent on the physical distance between Ca(V)2.1 and synaptic vesicles (coupling). Although various active zone proteins are pro...

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Vydáno v:eLife
Hlavní autoři: Lübbert, Matthias, Goral, R Oliver, Satterfield, Rachel, Putzke, Travis, van den Maagdenberg, Arn MJM, Kamasawa, Naomi, Young, Samuel M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548488/
https://ncbi.nlm.nih.gov/pubmed/28786379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.28412
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