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Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations

While limited drug loading continues to be problematic for chemotherapeutics formulated in nanoparticles, we found that we could take advantage of colloidal drug aggregation to achieve high loading when combined with polymeric excipients. We demonstrate this approach with two drugs, fulvestrant and...

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Bibliografiske detaljer
Udgivet i:Mol Pharm
Main Authors: Ganesh, Ahil N., Logie, Jennifer, McLaughlin, Christopher K., Barthel, Benjamin L., Koch, Tad H., Shoichet, Brian K., Shoichet, Molly S.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548416/
https://ncbi.nlm.nih.gov/pubmed/28502177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.6b01015
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