Colloidal Drug Formulations Can Explain “Bell-Shaped” Concentration–Response Curves

[Image: see text] Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration–response curves suggest more complex biological effects, such as multiple-binding sites or multiple target...

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Bibliografiske detaljer
Main Authors: Owen, Shawn C., Doak, Allison K., Ganesh, Ahil N., Nedyalkova, Lyudmila, McLaughlin, Christopher K., Shoichet, Brian K., Shoichet, Molly S.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985758/
https://ncbi.nlm.nih.gov/pubmed/24397822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4007584
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