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Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis
The indolocarbazole antitumor agent rebeccamycin is modified by chlorine atoms on each of two indole moieties of the aglycone scaffold. These halogens are incorporated during the initial step of its biosynthesis from conversion of l-Trp to 7-chlorotryptophan. Two genes in the biosynthetic cluster, r...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2005
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC554827/ https://ncbi.nlm.nih.gov/pubmed/15743914 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500755102 |
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