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Structure and Mechanism of the Rebeccamycin Sugar 4′-O-Methyltransferase RebM

The 2.65-Å crystal structure of the rebeccamycin 4′-O-methyltransferase RebM in complex with S-adenosyl-l-homocysteine revealed RebM to adopt a typical S-adenosylmethionine-binding fold of small molecule O-methyltransferases (O-MTases) and display a weak dimerization domain unique to MTases. Using t...

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Detalles Bibliográficos
Main Authors: Singh, Shanteri, McCoy, Jason G., Zhang, Changsheng, Bingman, Craig A., Phillips, George N., Thorson, Jon S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2008
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2504894/
https://ncbi.nlm.nih.gov/pubmed/18502766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800503200
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