Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils

The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition to protein fibrils, amyloid plaques also contain non-proteinaceous components, including glycosaminoglycans (GAGs). We have shown previously that the GAG low-molecular-weight heparin (LMWH) binds to Aβ40...

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Publicado en:J Mol Biol
Autores principales: Stewart, Katie L., Hughes, Eleri, Yates, Edwin A., Middleton, David A., Radford, Sheena E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548265/
https://ncbi.nlm.nih.gov/pubmed/28697887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.07.003
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