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Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils

The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition to protein fibrils, amyloid plaques also contain non-proteinaceous components, including glycosaminoglycans (GAGs). We have shown previously that the GAG low-molecular-weight heparin (LMWH) binds to Aβ40...

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Detalhes bibliográficos
Publicado no:J Mol Biol
Main Authors: Stewart, Katie L., Hughes, Eleri, Yates, Edwin A., Middleton, David A., Radford, Sheena E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548265/
https://ncbi.nlm.nih.gov/pubmed/28697887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.07.003
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