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Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils

The Aβ peptide forms extracellular plaques associated with Alzheimer's disease. In addition to protein fibrils, amyloid plaques also contain non-proteinaceous components, including glycosaminoglycans (GAGs). We have shown previously that the GAG low-molecular-weight heparin (LMWH) binds to Aβ40...

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Dades bibliogràfiques
Publicat a:J Mol Biol
Autors principals: Stewart, Katie L., Hughes, Eleri, Yates, Edwin A., Middleton, David A., Radford, Sheena E.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5548265/
https://ncbi.nlm.nih.gov/pubmed/28697887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2017.07.003
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