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Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β(40) (Aβ(40)) by the peptide fragment Aβ(16–22)

Understanding the structural mechanism by which proteins and peptides aggregate is crucial, given the role of fibrillar aggregates in debilitating amyloid diseases and bioinspired materials. Yet, this is a major challenge as the assembly involves multiple heterogeneous and transient intermediates. H...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Adv
Main Authors: Bunce, Samuel J., Wang, Yiming, Stewart, Katie L., Ashcroft, Alison E., Radford, Sheena E., Hall, Carol K., Wilson, Andrew J.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Association for the Advancement of Science 2019
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588359/
https://ncbi.nlm.nih.gov/pubmed/31245536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav8216
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