Molecular insights into the surface-catalyzed secondary nucleation of amyloid-β(40) (Aβ(40)) by the peptide fragment Aβ(16–22)

Understanding the structural mechanism by which proteins and peptides aggregate is crucial, given the role of fibrillar aggregates in debilitating amyloid diseases and bioinspired materials. Yet, this is a major challenge as the assembly involves multiple heterogeneous and transient intermediates. H...

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Bibliographische Detailangaben
Veröffentlicht in:Sci Adv
Hauptverfasser: Bunce, Samuel J., Wang, Yiming, Stewart, Katie L., Ashcroft, Alison E., Radford, Sheena E., Hall, Carol K., Wilson, Andrew J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588359/
https://ncbi.nlm.nih.gov/pubmed/31245536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aav8216
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