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Comparison of the protein–protein interfaces in the p53–DNA crystal structures: Towards elucidation of the biological interface
p53, the tumor suppressor protein, functions as a dimer of dimers. However, how the tetramer binds to the DNA is still an open question. In the crystal structure, three copies of the p53 monomers (containing chains A, B, and C) were crystallized with the DNA-consensus element. Although the structure...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC554805/ https://ncbi.nlm.nih.gov/pubmed/15738397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500215102 |
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