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Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design
IMPORTANCE: The heterogeneity of rate of clinical progression among patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminishes the power of clinical trials using disease-modifying agents. OBJECTIVE: To gain a better understanding of the factors that affect th...
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| Udgivet i: | JAMA Neurol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5547572/ https://ncbi.nlm.nih.gov/pubmed/28288263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.5953 |
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