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Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design

IMPORTANCE: The heterogeneity of rate of clinical progression among patients with Alzheimer disease leads to difficulty in providing clinical counseling and diminishes the power of clinical trials using disease-modifying agents. OBJECTIVE: To gain a better understanding of the factors that affect th...

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Detalhes bibliográficos
Publicado no:JAMA Neurol
Main Authors: Qian, Jing, T.Hyman, Bradley, Betensky, Rebecca A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547572/
https://ncbi.nlm.nih.gov/pubmed/28288263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2016.5953
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